Vitamin B12 & B Complex Drips and Shots: What They Help With and How They Work
- Samantha Pieterse
- Jul 15
- 8 min read
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Tired, Unfocused, or Moody? You Might Be Low on B Vitamins
If you’re pregnant, caring for young kids, or just simply running on empty, there’s a real chance your body is low on the nutrients it needs to keep you going.
That kind of deep, never-ending fatigue. The mental fog that won’t lift. The low mood, poor sleep, or lack of focus. These aren’t just signs of “being busy,” they often mean that your body is missing something.
B vitamins, including B12 and the whole B Complex group, are central to how your body produces energy, regulates mood, and supports your nervous system. When your levels drop, your body feels the effects.
A well-formulated vitamin drip or a quick B vitamin injection can offer support that works quickly and is absorbed better than most oral supplements or foods.
In this guide, we’ll walk you through what B12 and B Complex actually do, how drips and shots work, and who’s most likely to benefit.
B12 vs B Complex Vitamins: What’s the Difference and Which Do You Need?
While they’re often mentioned together, B12 and B complex aren’t the same thing.
Vitamin B12 (also known as cobalamin) is a single, powerful vitamin that plays a big role in energy production, red blood cell formation, and nerve function.
B complex, on the other hand, is a group of eight B vitamins (B1, B2, B3, B5, B6, B7 (biotin), B9 (folate), and B12) that work together to support your metabolism, nervous system, skin health, stress response, and more.
B12 is often given on its own as an injection or added to an IV drip when someone needs a focused energy boost or has a known deficiency. B complex is usually delivered through an IV drip and is ideal for people who need broad-spectrum support, like when you’re dealing with burnout, recovering from illness, or managing the demands of pregnancy or postpartum.
You don’t always need both, but many people benefit from a combination, especially during high-demand seasons like pregnancy, breastfeeding, or chronic stress.
At-a-Glance: B12 vs. B Complex
Feature | B12 | B Complex |
What it is | Single vitamin (Cobalamin) | Group of 8 B vitamins (B1–B12) |
Best for | Energy, nerves, and red blood cells | Energy, stress, metabolism, skin, and brain |
Common forms | Shots, IV drips | Drips, sometimes added to IVs or injections |
Pregnancy use | Safe & essential | Also important (esp. B6, folate) |
Who Should Consider Vitamin B12 & B Complex Drips and Shots?
Low levels of vitamin B can affect everything from your energy and mood to memory, sleep, and immune function. Since B vitamins are water-soluble and easily depleted by stress, illness, diet, or certain medications, many people become deficient without realising it.
Studies show that B12 deficiency is especially common in pregnant women, vegetarians, older adults, and people with digestive issues or chronic medication use, even in those who feel “fine” until they suddenly crash.
B12 and B Complex Injections or Drips Help if You Have Any of the Following:
Tired all the time, even after a full night’s sleep.
Foggy thinking, low mood, or feeling easily overwhelmed.
Vegetarian or vegan diet (low in natural B12 sources).
Pregnant or trying to conceive (higher B vitamin demands, especially folate and B6).
Recovering from illness or surgery, or if you get sick often.
Taking birth control, antacids, or chronic medications that interfere with absorption.
Older adults, or anyone with gut absorption issues (IBS, bariatric surgery, etc.).
Think this might be you?
Book a quick consult or B12 shot at Mums & Bums, we’ll guide you through the best option for your body.
B12 & B Complex Drips vs Shots: Which One Is the Best for You?
Not all vitamin boosters are created equal. When it comes to B12 and B complex, the way you receive them can make a real difference, especially if you're run-down, stressed, or struggling to bounce back from illness or pregnancy.
Vitamin injections (usually given as a quick jab into the muscle) are absorbed quickly and can give you noticeable results within 24 hours. They’re ideal for busy people who need a fast, simple boost. On the other hand, IV drips offer hydration alongside vitamins (and more vitamins can be administered at once), making them especially helpful for fatigue, burnout, or recovery when your body needs more than just a top-up.
Several studies have shown that intramuscular and intravenous B12 delivery is more effective than oral supplementation in people with deficiency or poor absorption. For many of our patients, the right option depends on their lifestyle, symptoms, and the urgency with which they need to feel better.
Drip | Shot | |
How it's given | Through a vein over 30–45 minutes | Small injection into the muscle |
Speed | Hydrates + vitamin boost = fast results | Absorbed quickly, usually within 24h |
When should you pick this type | Fatigue, burnout, and dehydration | Quick energy fix or top-up |

How B Complex Vitamins Help with Stress, Anxiety, and Mood Support
B complex vitamins aren’t just for energy. They’re involved in how your brain functions, how your body handles stress, and how balanced you feel from day to day. When you're under pressure or constantly running on empty, your body burns through B vitamins faster, especially B1, B3, B6, B9, and B12.
Research shows that low levels of B vitamins, particularly B6, folate (B9), and B12, are linked to symptoms of anxiety, irritability, and depression. Supplementing with a complete B Complex can help restore calm, improve mood, and support your nervous system during stressful periods, especially when delivered directly through a drip or injection.
This is one reason why B complex is often used in IV drips for postpartum moms, burnt-out professionals, and anyone feeling mentally or emotionally drained.
The Role of B Complex Vitamin for Stress and Mood
B6 (Pyridoxine): Supports neurotransmitters like serotonin and GABA, both linked to mood regulation and calm.
B1 (Thiamine) & B3 (Niacin): Aid energy production in the brain and support a healthy nervous system.
B9 (Folate) & B12 (Cobalamin): Critical for brain function, mental clarity, and preventing fatigue-related mood dips.
Overall effect: B complex may help ease anxiety, improve focus, and reduce mental fatigue, especially during periods of high stress or hormonal fluctuations.
Are B12 and B Complex Injections Safe in Pregnancy and Breastfeeding?
Both B12 and B Complex vitamins are not only safe during pregnancy and breastfeeding, but are also really important for your health and your baby’s development. During pregnancy, your body’s need for certain B vitamins increases significantly. B12, folate (B9), and B6 in particular play key roles in preventing birth defects, supporting fetal brain and nervous system development, and maintaining your energy and mood throughout pregnancy and postpartum.
In fact, the South African Department of Health and the WHO include folate and B12 in their standard nutritional recommendations for pregnant women. And for breastfeeding moms, these vitamins help replenish what your body gives away, support milk production, and reduce fatigue.
At our clinic, we use carefully selected B12 and B complex formulations that are safe for pregnancy and breastfeeding, and we personalize each drip or injection to your needs and symptoms.
Why B Vitamins Are Important for Moms
Folate (B9): Helps prevent neural tube defects and supports brain and spinal cord development.
B6 (Pyridoxine): Can ease nausea in the first trimester and supports hormone metabolism.
B12 (Cobalamin): Helps prevent maternal anemia, supports red blood cell formation, and boosts energy
We offer pregnancy-safe B12 and B complex drips and injections
And they're personalised for each trimester or breastfeeding stage.
Vitamin B12 & B Complex Injections & Drips: Are There Any Side Effects?
For most people, B12 and B Complex injections or drips are very safe and well-tolerated, especially when given in appropriate doses and by a trained professional. Side effects are rare and usually mild, but it’s still helpful to know what to expect.
Most of the time, if any reaction occurs, it’s due to how depleted your body is or how quickly your system adjusts to the boost. For example, people with very low B12 levels may feel slightly light-headed or tired for a few hours before they feel noticeably better, a sign that the body is actively responding.
Serious side effects are extremely uncommon, especially with intramuscular (IM) and IV administration using clinically appropriate doses. High-dose or poorly formulated over-the-counter products are more likely to cause issues than a medical-grade drip or injection from a reputable clinic.
Possible Side Effects (Usually Mild & Temporary)
Minor bruising or tenderness at the injection site.
Mild headache or light-headedness if you’re very depleted.
Temporary fatigue or sluggishness as your body adjusts (especially with first-time drips).
Tingling or flushing with very high doses of B3 or B6 (uncommon in clinical settings with proper dosing).

What to Expect at Your Vitamin B12 or B Complex Appointment
Whether you're coming in for a quick B12 shot or a full B Complex drip, the appointment is comfortable and takes less time than most lunch breaks. After a short chat about how you're feeling and any relevant health history, we’ll help you decide whether a drip or shot is best for your needs.
For injections, it's in and out within minutes. If you’re getting a drip, you’ll be seated comfortably while the vitamins are delivered through a small cannula over 30 to 45 minutes. Many people scroll or just take the opportunity to sit still and relax. Once it’s done, you're free to carry on with your day. Most clients go straight back to work, errands, or the school run.
How Long Does a Vitamin B Drip & Injection Take
B12 or B complex shot: About 5 minutes in total.
Vitamin drip with B12 and/or B complex: 30–45 minutes, including setup.
Afterward, no downtime. You can resume normal activities immediately.
We recommend staying hydrated before and after your visit, and having a light snack beforehand if you're prone to light-headedness.
FAQs About B12 & B Complex Drips and Shots
Can I get B12 and B complex together?
Yes, they’re commonly combined in IV drips or given as separate shots to support both targeted and broad-spectrum needs. This pairing is really helpful during pregnancy, high-stress periods, or recovery.
How often should I get a B12 or B complex injection?
It depends on your symptoms, lifestyle, and how your body responds to treatment. Some people benefit from weekly top-ups, while others maintain their levels with monthly visits.
Is a drip or injection better than oral B vitamins?
In many cases, yes, especially if you have gut absorption issues (e.g., IBS, low stomach acid, post-surgery) or if you’re already depleted. IV and IM delivery bypass the digestive system for faster, more effective absorption.
Do I need a script for a B12 or B complex shot or drip?
Not usually. You only need a referral if you have a complex medical history. Most healthy individuals can book directly after a quick screening.
Should You Try a B12 or B Complex Drip or Injection?
If you're always tired, running on fumes, or feeling mentally drained, no matter how much rest you get, it may not just be your schedule that's to blame. It could be your body quietly calling out for support.
Low B Vitamin levels are incredibly common, especially in pregnancy, during stressful seasons, or when your diet or digestion isn’t where it needs to be. A well-formulated B12 or B complex shot or drip might be exactly what your system has been missing, and for many people, the difference is noticeable within days. If something feels off, it’s worth checking in.
Ready to feel better, faster?
Book your pregnancy-safe B12 shot, quick B complex injection, or a relaxing vitamin drip at Mums & Bums in Centurion.
➡️ Book now or send us a WhatsApp to chat through your options. 🔸 Learn more about Vitamin B drips and benefits
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